e-ISSN 2395-3950, p-ISSN 2395-440X
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 294
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 168
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 237
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 317
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 358
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 294
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home1/irpmsom/public_html/application/controllers/Home.php
Line: 9
Function: library
File: /home1/irpmsom/public_html/index.php
Line: 315
Function: require_once
e-ISSN 2395-3950, p-ISSN 2395-440X
This to certify that International Research and Publications in Medical Sciences (IRPMS) editorial team has considered to present the best paper award to the corresponding author Kristine Joy G. Boholst, Noli A. Cabildo, David Vi for publishing his outstanding research paper in IRPMS, Volume-3, Issue-4, Oct-Dec entitled as 1. FACTORS FOR TUBERCULOSIS TREATMENT RELAPSE AMONG PATIENTS PREVIOUSLY TAKING CATEGORY 1 STANDARD TUBERCULOSIS TREATMENT REGIMEN IN SELECTED MUNICIPALITIES OF ILOCOS SUR.
editor@ irpms.com, irpmseditor@gmail.com +91 9427222776
Sachin A. Jain, Payal S. Jain, Sonia K Parikh, Shailesh S Talati, Shilin N Shukla
ABSTRACT
Background: Breast cancer is a major medical problem with significant public health and societal ramifications and is a leading cause of cancer death in women. Gene expression profiling has identified five subtypes of breast cancer (luminal A, luminal B, normal breast like, HER-2neu over expression, and basal-like), each of which has a different prognosis. Aims & Objectives: The aim of the present study to compare the expression of these biomarkers between primary and metastatic breast carcinoma. Material & Methods: All female patients ages >18 years diagnosed with metastatic breast cancer at the Gujarat Cancer and Research Institute from October 2010 to February 2013 were evaluated and taken into the study. The assessment of ER, PR and Her2 for the metastatic tissue was then compared with that of the primary tumour. Results: In our study the youngest patient was 25 years old and the eldest was 75 years old with an average age and median age was 45 years at the time of presentation with breast cancer. Estrogen receptor (ER) was positive in 15 (23%) and negative in 50 (77%) primary tumours while positive in 27 (42%) and negative in 38 (58%) metastatic tumours. Progesterone receptor (PR) was positive in 20 (31%) and negative in 45 (69%) primary tumours while positive in 24 (37%) and negative in 41 (63%) metastatic tumours. HER2 receptor was positive in 25 (38%) and negative in 40 (62%) primary tumours while positive in 22 (34%) and negative in 43 (66%) metastatic tumours. Conclusion: Our study demonstrates important differences in metastatic behaviour between the breast cancer subtypes as defined by a panel of immunohistochemical markers and contributes to an expanding knowledge of prognostic and predictive markers that will allow individualized therapy for metastatic breast cancer.
Key-words: Breast Cancer, Estrogen receptor, Progesterone receptor, HER2 receptor
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