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IRPMS | Abstract

e-ISSN 2395-3950, p-ISSN 2395-440X

Best Paper Award

This to certify that International Research and Publications in Medical Sciences (IRPMS) editorial team has considered to present the best paper award to the corresponding author Kristine Joy G. Boholst, Noli A. Cabildo, David Vi for publishing his outstanding research paper in IRPMS, Volume-3, Issue-4, Oct-Dec entitled as 1. FACTORS FOR TUBERCULOSIS TREATMENT RELAPSE AMONG PATIENTS PREVIOUSLY TAKING CATEGORY 1 STANDARD TUBERCULOSIS TREATMENT REGIMEN IN SELECTED MUNICIPALITIES OF ILOCOS SUR.

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International Research and Publications in Medical Sciences (IRPMS)
Dr. Shweta A. Pathak, Associate Editor
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editor@ irpms.com, irpmseditor@gmail.com +91 9427222776

Abstract

2. Study Of Vascular Endothelial Dysfunction In Patients with Diabetes Mellitus By Flow Mediated Dilation Of Brachial Artery,

Dinesh Choudhary, Jitendra Acharya, Rakesh Garg,

Int Res Pub Med Sci, 2015;1(3):7-16.

ABSTRACT

Background: Endothelial dysfunction (ED) has a pivotal role in the atherosclerosis and in atherosclerosis related diseases such as coronary artery disease. We aimed to diagnose ED in diabetes mellitus (DM) patients by Colour Doppler, B-mode ultrasound using ?ow mediated vascular responses [reactive hyperemia]. Methods & Results: We measured end-diastolic diameter of the brachial artery in longitudinal section at rest, after stress [Flow Mediated Dilation: FMD] and after 400 microgram nitroglycerin puff sublingually [Nitrate Mediated Dilation: NMD]. FMD & NMD in 20 control subjects & 40 DM patients were compared. There was no signi?cant difference [p > 0.05] in brachial artery diameter at rest [4.12+/-0.56 Vs 4.09+/- 0.50 mm in controls & cases respectively]. Non-DM group showed signi?cantly higher [p<0.05] FMD [9.48+/-5.63%] than DM group [6.00+/-2.92%]. NMD was marginally reduced in the DM group than Non-DM group [13.63+/-5.50 Vs 15.54+/-7.50%] but no signi?cant difference could be deduced [p>0.05]. Patients of DM with ?5 yrs duration had decreased FMD than those with DM of 0.05]. Conclusion: Signi?cant reduction in FMD was recorded in DM patients, signifying endothelial dysfunction. This non invasive method of FMD of brachial artery may diagnose the atherosclerotic stage in diabetic patients at a very early stage and should be used in all diabetic patients, especially in poorly controlled and long duration of DM but larger studies in this regard are needed to con?rm our ?ndings.

Key-words: Diabetes Mellitus, Endothelial dysfunction, Flow Mediated Dilation, Nitrate Mediated Dilation.


HOW TO CITE THIS ARTICLE:

Pubmed Style

Choudhary D, Acharya J, Garg R. Study Of Vascular Endothelial Dysfunction In Patients with Diabetes Mellitus By Flow Mediated Dilation Of Brachial Artery. Int Res Pub Med Sci. 2015; 1(3):7-16.

Web Style

Choudhary D, Acharya J, Garg R. Study Of Vascular Endothelial Dysfunction In Patients with Diabetes Mellitus By Flow Mediated Dilation Of Brachial Artery. http://irpms.com/home/article_abstract/62 [Access: Oct 11, 2015].

AMA (American Medical Association) Style

Choudhary D, Acharya J, Garg R. Study Of Vascular Endothelial Dysfunction In Patients with Diabetes Mellitus By Flow Mediated Dilation Of Brachial Artery. Int Res Pub Med Sci. 2015; 1(3): 7-16.

Vancouver/ICMJE Style

Choudhary D, Acharya J, Garg R. Study Of Vascular Endothelial Dysfunction In Patients with Diabetes Mellitus By Flow Mediated Dilation Of Brachial Artery. Int Res Pub Med Sci 2015; 1(3): 7-16.

Harvard Style

Choudhary D, Acharya J, Garg R. (2015) Study Of Vascular Endothelial Dysfunction In Patients with Diabetes Mellitus By Flow Mediated Dilation Of Brachial Artery. Int Res Pub Med Sci. 2015; 1(3): 7-16.


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