17. Chronic Neutrophilic Leukemia: A Rare Heterogenous Myeloproliferative Disorder,

Sant Prakash Kataria, Gajender Singh, Pansi Gupta, Uma Singh, Sanjay Kumar, Rajeev
Sen,

Int Res Pub Med Sci, 2015;1(3):103-106

ABSTRACT

Chronic Neutrophilic Leukemia (CNL) is a rare, infrequently recognized, myeloproliferative disorder. It usually manifests as a leukemoid reaction, with mostly mature granulocytes in the peripheral blood, with rare to occasional immature forms, and sometimes with normoblasts. Because this disease entity is very rare, and because it is typically a diagnosis of exclusion, it is important for pathologists and hematologists to, be familiar with Chronic Neutrophilic Leukemia (CNL) when approaching the patient with a myeloproliferative clinical picture. Thus, the objectives of this report are: 1) to detail the clinical case of a 52 year old male patient with initial presentation of hyperleukocytosis, 2) to review the differential diagnosis of a granulocytic myeloproliferative presentation and demonstrate the laboratory and clinical criteria utilized to establish a diagnosis of CNL in this case, and 3) to brie?y review the current literature on the diagnosis and treatment of CNL.

Key-words: Chronic neutrophilic leukemia, myeloproliferative disorder

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