13. Clinico-hematological Profile of Childhood Pancytopenia with Special References to Non Malignant Presentation

Ghanshyam Singh, Devendra Kumar Agrawal, Renu Agrawal, Prem Prakash Suthar

ABSTRACT

Background: Pancytopenia refers to a reduction in all the three formed elements of blood: red blood cells, white blood cells and platelets. There is scarcity of such data on pediatric patients, and to the best of our knowledge, no study has analyzed adult or pediatric bicytopenic patients. Aims: The aim of this study was to evaluate the clinico-hematological profile of children with bicytopenia/pancytopenia. Material & Methods: Patient’s age group between 6 months to 15 years from 1st September 2014 to 31st August 2015 admitted in children hospital, S.P. Medical College, Bikaner was selected for this study. Pancytopenia was reported by automated cell counter “Symex CBC 18PAR KX-21”. Hemoglobin <10gm%, TLC <4000mm3 and Platelet count <1 Lac/mm3 were taken as criteria of pancytopenia. Platelet count was confirmed by PBF manually. Results: The majority of patients belonged to age group 1-5 years (51.6%) in non-malignant etiology in pancytopenia patients from a rural area (77.1%) and lower upper socioeconomic status (41.2%). According to PBF expert, the majority of the patients had pancytopenia with dimorphic anemia (32%). Conclusion: Dimorphic anemia in PBF examination was the most common finding in cases of pancytopenia due to severe malnutrition. 18.2% cases of pancytopenia were of malignant etiology, out of them maximum were of ALL. Key-words: Pancytopenia, Hematological examination, Peripheral blood film, Hemoglobin

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