3. Correlation Between Mean Corpuscular Volume, Vitamin B12 And Haemoglobin Level In Patients With Neurological Disorders.

Gautam Kumar Bunker, Tarun Kumar Ralot, Manoj Kumar Arya

ABSTRACT

Objectives: vitamin B12 is a micronutrient essential for neuro-cognitive, haemopoietic and cardiovascular function. This study was planned to find out the correlation between vitamin B12 deficiency and its haematological effect like haemoglobin and MCV. Material and Methods: In this cross sectional study, 100 patients presented in the department of Neurology and Internal Medicine R.N.T. Medical College, Udaipur from 1st January 2015 to 30th June 2016, with neurological disorders and in whom vitamin B 12 was diagnosed were analyzed. After detail history and careful examination, blood was sent for CBC and vitamin B12 level. Routine investigations too were done in the 1study subjects. Information had then filled in the predesigned proforma for analysis. Results: there were 37 male and 63 female and the male to female ration was 1: 1.7. Maximum numbers of the patient were under 50 year of age. Out of 100 vitamin B12 deficient patients, only 10% patients had MCV above 100fl. In this study 54 (54%) patients were anaemic out of these 39 (72.22%), 13 (24.07%) and 2 (3.70%) were mild, moderate and sever anaemic. Conclusion: there was no correlation between vitamin B12 and MCV level in the study subjects. In patients with neurological disorders, vitamin B12 deficiency should be suspected irrespective of their MCV and haemoglobin level.

Key-Words: Vitamin B12 , haemopoetic, megaloblastic anaemia, MCV

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