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IRPMS | Abstract

e-ISSN 2395-3950, p-ISSN 2395-440X

Best Paper Award

This to certify that International Research and Publications in Medical Sciences (IRPMS) editorial team has considered to present the best paper award to the corresponding author Kristine Joy G. Boholst, Noli A. Cabildo, David Vi for publishing his outstanding research paper in IRPMS, Volume-3, Issue-4, Oct-Dec entitled as 1. FACTORS FOR TUBERCULOSIS TREATMENT RELAPSE AMONG PATIENTS PREVIOUSLY TAKING CATEGORY 1 STANDARD TUBERCULOSIS TREATMENT REGIMEN IN SELECTED MUNICIPALITIES OF ILOCOS SUR.

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Dr. Shweta A. Pathak, Associate Editor
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editor@ irpms.com, irpmseditor@gmail.com +91 9427222776

Abstract

9. Total Antioxidant Activity And Oxidative Stress In Rheumatoid Arthritis Patients

Manisha Sharma, Manish Kumar Sharma, A.K. Verma

ABSTRACT

Background: Rheumatoid arthritis (RA) is a chronic multisystem disease of unknown cause. It is believed that increased formation of oxidative stress and decreased antioxidant status are the hallmarks in these patients as observed in recent years. Aims & Objective: To analyze the total antioxidant activity and oxidative stress in rheumatoid arthritis patients. Method: Blood glutathione, uric acid, total antioxidant activity (TAA), malondialdehyde (MDA), vitamin C, ESR along with Rheumatoid Factor (RF) were measured in 300 patients affected by rheumatoid arthritis and the results were compared with a group of 200 normal subjects. Results: Mean serum level of MDA and uric acid were found to be significantly high (P < 0.001). The mean level of glutathione showed significantly decreased p value (P<0.05), while the erythrocyte sedimentation rate (ESR) was higher. The level of TAA and vitamin C was found to be significantly lower (P < 0.01) than the normal subjects. Conclusion: Data suggests that the decreased level of glutathione, vitamin C and TAA and elevated levels of serum MDA and uric acid as a result of homostatic imbalance between antioxidant defence system and enzymatic antioxidants.

Key-words: Glutathione, Malondialdehyde, erythrocyte sedimentation rate, total antioxidant activity, rheumatoid arthritis, rheumatoid arthritic factor, Dithiobis Nitrobenzoic acid.


HOW TO CITE THIS ARTICLE:

Pubmed Style

Sharma M, Sharma MK, Verma AK. Total Antioxidant Activity And Oxidative Stress In Rheumatoid Arthritis Patients Int Res Pub Med Sci. 2016; 2(3) :47-46.

Web Style

Sharma M, Sharma MK, Verma AK. Total Antioxidant Activity And Oxidative Stress In Rheumatoid Arthritis Patients. http://irpms.com/home/article_abstract/163 [Access: Oct 15, 2016].

AMA (American Medical Association) Style

Sharma M, Sharma MK, Verma AK. Total Antioxidant Activity And Oxidative Stress In Rheumatoid Arthritis Patients. Int Res Pub Med Sci. 2016; 2(3) :47-46.

Vancouver/ICMJE Style

Sharma M, Sharma MK, Verma AK. Total Antioxidant Activity And Oxidative Stress In Rheumatoid Arthritis Patients Int Res Pub Med Sci 2016; 2(3) :47-46.

Harvard Style

Sharma M, Sharma MK, Verma AK.(2016) Total Antioxidant Activity And Oxidative Stress In Rheumatoid Arthritis Patients. Int Res Pub Med Sci. 2(3) :47-46.


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