e-ISSN 2395-3950, p-ISSN 2395-440X
e-ISSN 2395-3950, p-ISSN 2395-440X
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Manisha Sharma, A.K. Verma, Manish Kumar Sharma
ABSTRACT
Background: Rheumatoid arthritis (RA) is a systemic disease characterized by progressive erosive and chronic polyarthritis. The etiology of RA is unknown, but some evidences suggest the involvement of reactive oxygen species (ROS) in pathogenesis of the disease. Objective: To evaluate enzymatic antioxidant status by measuring vitamin E, total antioxidant activity, malondialdehyde (MDA) in serum of the RA patients along with uric acid, total Thiol, C-reactive protein (CRP), rheumatoid factor (RF) and to investigate the effect of diet and hypertension in RA patients as compared to the control. Method: 300 patients with rheumatoid arthritis and 200 apparently healthy subjects were studied and serum malondialdehyde, uric acid were measured by enzymatic method, vitamin E by Netelson (1971) and total antioxidant activity according to Benzie and Strain (1999) and also Thiol by DTNB method. Results: The data obtained showed that the level of uric acid, MDA were significantly higher in the patients with RA as compared to the healthy controls, while total Thiol, vitamin E and total antioxidant were lower in RA patient as compared to the controls. Conclusion: The pathogenesis of RA contributed by antioxidant and number of hypertensive people were higher in RA compared to control.
Key-words: Rheumatoid arthritis, Reactive oxygen species, Antioxidant activity, Malondialdehyde, Rheumatoid factor, Vitamin E.
HOW TO CITE THIS ARTICLE:
Pubmed Style
Sharma M, Verma AK, Sharma MK. Enzymatic Antioxidant Status, Malondialdehyde and Total
Antioxidant Activity as Maker of Oxidative Stress in Rheumatoid Arthritis. Int Res Pub Med Sci. 2016; 2(3) : 72-75.
Web Style
Sharma M, Verma AK, Sharma MK. Enzymatic Antioxidant Status, Malondialdehyde and Total
Antioxidant Activity as Maker of Oxidative Stress in Rheumatoid Arthritis.
http://irpms.com/home/article_abstract/167 [Access: Oct 15, 2016].
AMA (American Medical Association) Style
Sharma M, Verma AK, Sharma MK. Enzymatic Antioxidant Status, Malondialdehyde and Total
Antioxidant Activity as Maker of Oxidative Stress in Rheumatoid Arthritis. Int Res Pub Med Sci. 2016; 2(3) : 72-75.
Vancouver/ICMJE Style
Sharma M, Verma AK, Sharma MK. Enzymatic Antioxidant Status, Malondialdehyde and Total
Antioxidant Activity as Maker of Oxidative Stress in Rheumatoid Arthritis. Int Res Pub Med Sci 2016; 2(3) : 72-75.
Harvard Style
Sharma M, Verma AK, Sharma MK.(2016) Enzymatic Antioxidant Status, Malondialdehyde and Total Antioxidant Activity as Maker of Oxidative Stress in Rheumatoid Arthritis. Int Res Pub Med Sci. 2(3) : 72-75.
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