8. Glomerular Filtration Rate Estimation with the Diethylene Triamine Penta-acetic Acid (DTPA) Camera Method in Indian Healthy Donors and Comparison with Modified Diet in Renal Disease Formula (four variable)-Our Experience

Dr. Rajeev Kumar, Dr. MS Chauhan, Dr. Amit Sharma and Dr. Anurag Jain

IRPMS, 2015; 1(2): 33-39.
 

ABSTRACT

Background: Chronic kidney disease (CKD) encompasses a spectrum of different path physiological processes associated with abnormal kidney function and a progressive decline in glomerular filtration rate (GFR). Due to increasing in the number of cases of Chronic kidney disease Stage-V, there is higher demand of renal transplantation for which there is a need of healthy donors. Presently the criteria for renal donor is a globally accepted creatinine based GFR estimation method which are mostly accepted globally as a marker, however, there is a lack of an easily available, cheap, reliable and reproducible GFR marker. Diethylene Triamine Pentaacetic Acid (DTPA) camera method is a potential method to be used in place of modification of diet in renal disease method (MDRD) of GFR estimation. Aims & Objectives: The present study was undertaken to know the comparison of DTPA method and the MDRD formula of GFR estimation in healthy individuals of Indian origin. Methods: The present study is a prospective and observational study, which was conducted in the Department of Nuclear Medicine, Army Hospital R&R Delhi Cantt. All the cases of renal donors, which were brought to us for GFR estimation during the two year period from January 2011 to December 2012 were selected for this study to find out the , GFR. Results: In our study most of the donors were mostly female in their 4 decade of life because of the fact that our hospital is military hospital and most of the families are nuclear family which are very far from their native place and most of the female mostly wife are willing to donate the kidney for their husbands. GFR estimation by MDRD formula in healthy donor GFR ranged from 51 to 161 ml/min with a mean GFR 99.40± 25.14 ml/min, while GFR estimation by DTPA in healthy donor ranged from 72.3 to 141.9 ml/min with a mean GFR 99.97± 16.45ml/min. There was a significant positive correlation between DTPA and MDRD (r = 0.372 with p: 0.002) method. Conclusion: Our study shows that the DTPA renogram using Gamma Camera will give not only the measured GFR but also it will help clinician to know the other valuable information like size and outline of kidney, relative function and excretory performance of the kidney.

Key-words: GFR, MDRD, DTPA and Gamma camera.

 

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